![]() Do not abruptly discontinue in the physically dependent patient.Monitor for signs and symptoms of withdrawal if they occur, raise the dose to the previous level and taper more slowly.Taper dose gradually, by 25% to 50% every 2 to 4 days.A conservative approach is recommended due to wide inter-patient variability in response to the potency of opioid drugs and formulations it is safer to underestimate than overestimate and manage an adverse reaction due to overdose.Ĭoncomitant use of CYP450 3A4 inducers or inhibitors may require dose adjustment: Consult drug interactionsĭiscontinuation of Therapy in the Physically Dependent Patient:.To avoid overdose of acetaminophen, it is best to use just 1 acetaminophen product at a time.Take into account all acetaminophen products when calculating daily dose.Maximum Acetaminophen Dose is 4 g in 24 hours Dose AdjustmentsĪcetaminophen-hydrocodone should be used with caution in elderly or debilitated patients and those with hypothyroidism, Addison's disease, prostatic hypertrophy or urethral stricture generally, start at the lower end of the dosing range and titrate carefully. ![]() Liver Dose AdjustmentsĬaution recommended patients with hepatic impairment may have higher hydrocodone plasma concentrations monitor closely for adverse events. Renal Dose AdjustmentsĬaution recommended patients with renal impairment may have higher hydrocodone plasma concentrations monitor closely for adverse events. Use: For the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.
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